Search Result
Gene Summary for H19 Gene
| Official Symbol |
H19 |
Gene Type |
lncRNA |
| Full Name |
H19 imprinted maternally expressed transcript |
Entrez |
283120
|
| Ensembl ID |
ENSG00000130600 |
HGNC |
4713
|
| Aliases |
ASM, ASM1, BWS, D11S813E, LINC00008, MIR675HG, NCRNA00008, WT2
|
Chromosome Location |
Chromosome 11, NC_000011.10 (1995176..2001466, complement)
|
| Expression |
Biased expression in placenta (RPKM 2773.7), adrenal (RPKM 234.1) and 2 other tissues
|
| Summary |
This gene is located in an imprinted region of chromosome 11 near the insulin-like growth factor 2 (IGF2) gene. This gene is only expressed from the maternally-inherited chromosome, whereas IGF2 is only expressed from the paternally-inherited chromosome. The product of this gene is a long non-coding RNA which functions as a tumor suppressor. Mutations in this gene have been associated with Beckwith-Wiedemann Syndrome and Wilms tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
|
Paper for H19 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28848149 |
Jin Yan |
2017 |
H19 |
A novel regulatory pathway H19/miR-675/ FADD/caspase 8/caspase 3 in gastric cancer which may be potential target for cancer therapy. |
Experiment for H19 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
34 |
34 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
H19 was increased in gastric cancer cell lines and tissues. Overexpression of H19 promoted cell proliferation and inhibited cell apoptosis, whereas knockdown of H19 inhibited these effects. By further examining the underlying mechanism, we showed that H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. |
28848149 |
| cell line |
- |
- |
Cell proliferation assay; Colony formation assay; Flow cytometry |
- |
No Reports |
- |
- |
Overexpression of H19 and miR-675 promoted cell proliferation and inhibited cell apoptosis, whereas knockdown of H19 and miR-675 inhibited these effects. |
Overexpression of H19 and miR-675 promoted cell proliferation and inhibited cell apoptosis, whereas knockdown of H19 and miR-675 inhibited these effects. |
28848149 |
Function for H19 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for H19 Gene
| Interaction Gene |
Method |
PMID |
|
