Search Result
Gene Summary for HOTAIR Gene
| Official Symbol |
HOTAIR |
Gene Type |
lncRNA |
| Full Name |
HOX transcript antisense RNA |
Entrez |
100124700
|
| Ensembl ID |
ENSG00000228630 |
HGNC |
33510
|
| Aliases |
HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072
|
Chromosome Location |
Chromosome 12, NC_000012.12 (53962308..53974956, complement)
|
| Expression |
Biased expression in testis (RPKM 1.6), skin (RPKM 1.2) and 6 other tissues
|
| Summary |
This gene is located within the Homeobox C (HOXC) gene cluster on chromosome 12 and is co-expressed with the HOXC genes. It functions through an RNA product, which binds lysine specific demethylase 1 (LSD1) and Polycomb repressive complex 2 (PRC2), and serves as a scaffold to assemble these regulators at the HOXD gene cluster, thereby promoting epigenetic repression of HOXD. This gene is highly expressed in multiple tumors. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Feb 2019]
|
Paper for HOTAIR Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30810117 |
Datong Jiang |
2019 |
HOTAIR |
lncRNA HOTAIR knockdown stimulates miR-454-3p expression to inhibit gastric cancer growth by depressing STAT3/Cyclin D1 activity. |
Experiment for HOTAIR Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
30 |
30 |
ISH |
China |
No Reports |
Up |
- |
- |
HOTAIR expression of cancer tissues was significantly increased compared with that of non_x005ftumor tissues; lncRNA HOTAIR was negatively correlated with miR-454-3p expression in gastric cancer tissues. |
30810117 |
| cell line |
- |
- |
Cell proliferation assay; Flow cytometry |
- |
No Reports |
- |
- |
HOTAIR knockdown had anti-tumor effects that suppressed gastric cancer cell proliferation by increasing cell apoptosis and keeping the cell cycle in G1 phase. |
HOTAIR knockdown had anti-tumor effects that suppressed gastric cancer cell proliferation by increasing cell apoptosis and keeping the cell cycle in G1 phase. |
30810117 |
Function for HOTAIR Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for HOTAIR Gene
| Interaction Gene |
Method |
PMID |
|
