Search Result
Gene Summary for HOXA1 Gene
| Official Symbol |
HOXA1 |
Gene Type |
protein-coding |
| Full Name |
homeobox A1 |
Entrez |
3198
|
| Ensembl ID |
ENSG00000105991 |
HGNC |
5099
|
| Aliases |
BSAS, HOX1, HOX1F
|
Chromosome Location |
Chromosome 7, NC_000007.14 (27092993..27096000, complement)
|
| Expression |
Biased expression in urinary bladder (RPKM 4.0), skin (RPKM 1.0) and 13 other tissues
|
| Summary |
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. [provided by RefSeq, Jul 2008]
|
Paper for HOXA1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 26791264 |
Chenwei Yuan |
2016 |
HOXA1 |
HOXA1 plays a crucial role in GC development and clinical prognosis. HOXA1, alone or combination with cyclin D1, may serve as a novel prognostic biomarker for GC. |
Experiment for HOXA1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
48 |
48 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
HOXA1 mRNA expression were upregulated in GC tissues. Survival analysis indicated that HOXA1 expression were significantly associated with disease-free survival (DFS) and overall survival (OS). Patients with tumors that were positive for HOXA1 expression showed worse prognosis. Multivariate analysis confirmed that the combination of HOXA1 and cyclin D1 was an independent prognostic indicator for OS and DFS. |
26791264 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; Cell colony formation assay; Flow cytometry |
- |
No Reports |
- |
- |
Knockdown of HOXA1 in GC cells inhibited cell proliferation, migration, and invasion in vitro; Knockdown of HOXA1 expression induces changes in the cell cycle of GC cells and decreases cyclin D1 expression |
Knockdown of HOXA1 in GC cells inhibited cell proliferation, migration, and invasion in vitro; Knockdown of HOXA1 expression induces changes in the cell cycle of GC cells and decreases cyclin D1 expression |
26791264 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
Knockdown of HOXA1 suppressed xenograft tumor formation in vivo |
26791264 |
| tissue |
264 |
264 |
IHC |
China |
No Reports |
Up |
- |
- |
There was a correlation between HOXA1 and cyclin D1 in GC; |
26791264 |
Function for HOXA1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
< 0.001 |
< 0.001 |
Interaction for HOXA1 Gene
| Interaction Gene |
Method |
PMID |
|
