Search Result
Gene Summary for HSPB8 Gene
| Official Symbol |
HSPB8 |
Gene Type |
protein-coding |
| Full Name |
heat shock protein family B (small) member 8 |
Entrez |
26353
|
| Ensembl ID |
ENSG00000152137 |
HGNC |
30171
|
| Aliases |
CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HSP22
|
Chromosome Location |
Chromosome 12, NC_000012.12 (119178931..119194746)
|
| Expression |
Broad expression in heart (RPKM 181.8), esophagus (RPKM 96.6) and 15 other tissues
|
| Summary |
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
|
Paper for HSPB8 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29693129 |
Jian Shen |
2018 |
HSPB8 |
HSPB8 promotes cancer cell growth by activating the ERK-CREB pathway and may serve as a potential prognostic factor in GC patients. |
Experiment for HSPB8 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Cell proliferation assay; Flow cytometry |
- |
No Reports |
- |
- |
- |
Knockdown of HSPB8 inhibits gastric cancer cell proliferation, promotes gastric cancer cell apoptosis |
29693129 |
Function for HSPB8 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for HSPB8 Gene
| Interaction Gene |
Method |
PMID |
|
