Search Result
Gene Summary for ITGA3 Gene
| Official Symbol |
ITGA3 |
Gene Type |
protein-coding |
| Full Name |
integrin subunit alpha 3 |
Entrez |
3675
|
| Ensembl ID |
ENSG00000005884 |
HGNC |
6139
|
| Aliases |
VL3A; CD49C; FRP-2; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3
|
Chromosome Location |
Chromosome 17, NC_000017.11 (50056065..50090481)
|
| Expression |
Broad expression in lung (RPKM 53.0), thyroid (RPKM 21.5) and 19 other tissues
|
| Summary |
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]
|
Paper for ITGA3 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 23533596 |
Yue-Ming Yang |
2013 |
integrin a3 |
CD151 is positively associated with the invasiveness of HGC, and CD151 or the combination of CD151 and integrin a3 is a novel marker for predicting the prognosis of HGC patients and may be potential therapeutic targets. |
Experiment for ITGA3 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
76 |
- |
IHC |
China |
No Reports |
- |
- |
- |
The membranes of tumor cells stained positive for integrin a3. In all the tissues analyzed, high levels of integrin a3 expression were detected in 27 HGC tissue samples (35.52%).Patients with high integrin a3 expression were more likely to exhibit aggressive features. Patients with high Integrin a3 showed larger tumors (p =3.46E24), greater depth of invasion (p =0.001), higher tumor stage (p = 0.005), and more lymph node involvement (p = 0.040) than patients with low integrin a3 expression. Overexpression of Integrin a3 is Independent Factors Predicting the Prognosis of HGC Patients. |
23533596 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays |
- |
No Reports |
- |
- |
silencing of integrin a3 markedly inhibited the invasion of HGC27 cells. |
silencing of integrin a3 markedly inhibited the invasion of HGC27 cells. |
23533596 |
| cell line |
- |
- |
Co-ip assays |
- |
No Reports |
- |
- |
- |
CD151 formed a complex with integrin a3 in HGC cells. |
23533596 |
Function for ITGA3 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target/prognosis |
- |
< 0.0001 |
- |
Interaction for ITGA3 Gene
| Interaction Gene |
Method |
PMID |
|
