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Gene Summary for JAZF1 Gene
| Official Symbol |
JAZF1 |
Gene Type |
protein-coding |
| Full Name |
JAZF zinc finger 1 |
Entrez |
221895
|
| Ensembl ID |
ENSG00000153814 |
HGNC |
28917
|
| Aliases |
TIP27, ZNF802
|
Chromosome Location |
Chromosome 7, NC_000007.14 (27830573..28180795, complement)
|
| Expression |
Broad expression in adrenal (RPKM 50.1), endometrium (RPKM 20.1) and 20 other tissues
|
| Summary |
This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]
|
Paper for JAZF1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 31357957 |
Jia-Wei Mei |
2019 |
JAZF1 |
Increased miR-1275 expression inhibited GC metastasis by regulating vimentin/E-cadherin via direct suppression of JAZF1expression, suggesting that miR-1275 is a tumour-suppressor miRNA with the potential as a prognostic biomarker or therapeutic target in GC. |
Experiment for JAZF1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
JAZF1 is a direct target of miR-1275 in GC cells. |
31357957 |
| tissue |
120 |
120 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
JAZF1 expression was increased in GC tissues and was positively associated with lymph node metastasis and Borrmann type. Better OS in GC patients with lower JAZF1 expression than in patients with higher JAZF1 expression. |
31357957 |
Function for JAZF1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
<0.001 |
- |
Interaction for JAZF1 Gene
| Interaction Gene |
Method |
PMID |
|
miR-1275 |
Luciferase reporter assay |
31357957
|
|
