MKGC: a curated molecular knowledgebase for gastric cancer


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Gene Summary for KDM4B Gene

Official Symbol KDM4B Gene Type protein-coding
Full Name lysine demethylase 4B Entrez 23030
Ensembl ID ENSG00000127663 HGNC 29136
Aliases JMJD2B, TDRD14B Chromosome Location Chromosome 19, NC_000019.10 (4969087..5153603)
Expression Ubiquitous expression in prostate (RPKM 5.2), thyroid (RPKM 5.0) and 25 other tissues
Summary -

Paper for KDM4B Gene

PMID Author Year ID in Paper
Conclusion
24077348 Li Zhao 2013 JMJD2B The data reveal a novel function of JMJD2B in promoting EMT and gastric cancer invasion and metastasis, implicating JMJD2B as a potential target for reversing EMT and intervention of the progression of gastric cancer.

Experiment for KDM4B Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
cell line - - Phase-contrast microscopy - No Reports - - - JMJD2B inhibition induces the epithelial morphology of gastric cancer cells 24077348
cell line - - qRT-PCR; Western blot - No Reports - - - JMJD2B repression results in downregulation of mesenchymal markers and upregulation of epithelial markers 24077348
cell line - - Luciferase reporter activity assay; ChIP assay; - No Reports - - - JMJD2B is physically associated with b-catenin to regulate vimentin promoter. 24077348
cell line - - Cell invasion and migration assay - No Reports - - JMJD2B inhibition results in diminished invasion and metastasis in vitro JMJD2B inhibition results in diminished invasion and metastasis in vitro 24077348
mice - - Xenograft mice models - No Reports - - - JMJD2B knockdown inhibits tumor metastasis in vivo. 24077348
tissue 101 - IHC China No Reports - - - JMJD2B expression was positively correlated with tumor size, differen_x005ftiation status, invasion, lymph node status, distant metastasis, and TNM stage of patients with gastric cancer 24077348

Function for KDM4B Gene

Functional Type AUC Overall Survival Disease-free Survival
target - - -

Interaction for KDM4B Gene

Interaction Gene Method PMID
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