Search Result
Gene Summary for LINC01089 Gene
| Official Symbol |
LINC01089 |
Gene Type |
lncRNA |
| Full Name |
long intergenic non-protein coding RNA 1089 |
Entrez |
338799
|
| Ensembl ID |
ENSG00000212694 |
HGNC |
27886
|
| Aliases |
LIMT
|
Chromosome Location |
Chromosome 12, NC_000012.12 (121795267..121802946, complement)
|
| Expression |
Ubiquitous expression in spleen (RPKM 8.0), prostate (RPKM 8.0) and 24 other tissues
|
| Summary |
-
|
Paper for LINC01089 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29717028 |
Yeqian Zhang |
2018 |
AK096174 |
The findings of the present study establish a function for AK096174 in GC progression and suggest it may serve as a potential target for GC therapy in the future. |
Experiment for LINC01089 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
32 |
32 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
lncRNA AK096174 was up-regulated and associated with tumorigenesis, tumor size, metastasis, and poor prognosis in GC. Our data showed that AK096174 was highly expressed in the GC tissues and cell lines (SGC-7901, AGS, BGC-823, MGC-803), and patients with higher AK096174 expression had a poorer prognosis and shorter overall survival (OS). AK096174 knockdown inhibited the proliferation, migration, and invasiveness in SGC-7901 and BGC-823 cells, whereas AK096174 overexpression had the promoting effects. Furthermore, mechanistic investigation showed that AK096174 positively correlated with the expression of WD repeat-containing protein 66 (WDR66) gene at the translational level. Knockdown of WRD66 attenuated the positive impact of AK096174 in GC cells |
29717028 |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion and migration assays; |
- |
No Reports |
- |
- |
AK096174 knockdown inhibited the proliferation, migration, and invasiveness in SGC-7901 and BGC-823 cells, whereas AK096174 overexpression had the promoting effects. |
AK096174 knockdown inhibited the proliferation, migration, and invasiveness in SGC-7901 and BGC-823 cells, whereas AK096174 overexpression had the promoting effects. |
29717028 |
Function for LINC01089 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for LINC01089 Gene
| Interaction Gene |
Method |
PMID |
|
