MKGC: a curated molecular knowledgebase for gastric cancer


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Gene Summary for LINC01234 Gene

Official Symbol LINC01234 Gene Type lncRNA
Full Name long intergenic non-protein coding RNA 1234 Entrez 100506465
Ensembl ID ENSG00000249550 HGNC 49757
Aliases LCAL84, onco-lncRNA-32 Chromosome Location Chromosome 12, NC_000012.12 (113744577..113773683, complement)
Expression Biased expression in brain (RPKM 1.1) and testis (RPKM 0.5)
Summary -

Paper for LINC01234 Gene

PMID Author Year ID in Paper
 Conclusion
29386218 Xin Chen 2018 LINC01234 LINC01234 is significantly overexpressed in gastric cancer, and LINC01234-miR-204-5p-CBFB axis plays a critical role in gastric cancer tumorigenesis.

Experiment for LINC01234 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 50 50 qRT-PCR China No Reports Up - - LINC01234 expression was significantly upregulated in gastric cancer tissues and was associated with larger tumor size, advanced TNM stage, lymph node metastasis, and shorter survival time. 29386218
cell line - - Cell proliferation assay; Invasion and migration assays; Flow cytometry - No Reports - - promote cell proliferation and cell tomorigenesis, suppress apotosis and G1 arrest promote cell proliferation and cell tomorigenesis, suppress apotosis and G1 arrest 29386218
mice - - Xenograft mice models - No Reports - - - knockdown of LINC01234-induced apoptosis and growth arrest in vitro and inhibited tumorigenesis in mouse xenografts. 29386218
cell line - - Immunoprecipitation assays - No Reports - - - LINC01234 binds directly to Ago2 29386218
cell line - - Luciferase reporter assay - No Reports - - - miR-204-5p directly target LINC01234 29386218

Function for LINC01234 Gene

Functional Type AUC Overall Survival Disease-free Survival
prognosis - <0.001 <0.001

Interaction for LINC01234 Gene

Interaction Gene Method PMID
Ago2;miR-204-5p Luciferase reporter assay 29386218
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