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Gene Summary for MAPK1 Gene
| Official Symbol |
MAPK1 |
Gene Type |
protein-coding |
| Full Name |
mitogen-activated protein kinase 1 |
Entrez |
5594
|
| Ensembl ID |
ENSG00000100030 |
HGNC |
6871
|
| Aliases |
ERK, ERK-2, ERK2, ERT1, MAPK2, NS13, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK
|
Chromosome Location |
Chromosome 22, NC_000022.11 (21759657..21867680, complement)
|
| Expression |
Ubiquitous expression in brain (RPKM 63.3), thyroid (RPKM 32.9) and 25 other tissues
|
| Summary |
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
|
Paper for MAPK1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 32293550 |
Min Luo |
2020 |
MAPK1 |
Knockdown of LINC00483 inhibited gastric cancer development in vitro and in vivo by increasing miR-490-3p and decreasing MAPK1, elucidating a novel mechanism for understanding the development of gastric cancer. |
Experiment for MAPK1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
30 |
30 |
qRT-PCR; Western blot |
China |
No Reports |
Up |
- |
- |
The mRNA level and protein level of MAPK1 were increased in gastric cancer tissues and cells. There was a positive correlation between levels of MAPK1 and LINC00483 in gastric cancer tissues. |
32293550 |
| cell line |
- |
- |
Cell viability assay; Invasion and migration assay; Flow cytometry |
- |
No Reports |
- |
- |
Knockdown of MAPK1 inhibited cells viability, migration and invasion but promoted apoptosis in gastric cancer cells. Moreover, MAPK1 overexpression attenuated the effect of LINC00483 knockdown on gastric cancer development. LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483. |
Knockdown of MAPK1 inhibited cells viability, migration and invasion but promoted apoptosis in gastric cancer cells. Moreover, MAPK1 overexpression attenuated the effect of LINC00483 knockdown on gastric cancer development. LINC00483 could increase MAPK1 expression by competitively sponging miR-490-3p. miR-490-3p overexpression suppressed gastric cancer development, which was abated by introduction of LINC00483. |
32293550 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
LINC00483 positively regulated MAPK1 by sponging miR‑490‑3p in gastric cancer cells |
32293550 |
Function for MAPK1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MAPK1 Gene
| Interaction Gene |
Method |
PMID |
|
miR-490-3p |
Luciferase reporter assay |
32293550
|
|
