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Gene Summary for MIR103A1 Gene
| Official Symbol |
MIR103A1 |
Gene Type |
miRNA |
| Full Name |
microRNA 103a-1 |
Entrez |
406895
|
| Ensembl ID |
ENSG00000199035 |
HGNC |
31490
|
| Aliases |
MIR103-1, MIRN103-1, mir-103a-1
|
Chromosome Location |
Chromosome 5, NC_000005.10 (168560896..168560973, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR103A1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29754469 |
Xiaoyi Hu |
2018 |
miRNA-103a-3p |
miR-103a-3p promotes the proliferation of GC cell by targeting and suppressing ATF7 in vitro |
Experiment for MIR103A1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
33 |
33 |
qRT-PCR |
China |
No Reports |
|
- |
- |
miR-103a-3p expression was regulated in GC tissues when compared with non-tissue samples, and was also upregulated in 18 poorly differentiated tumor tissues or in 24 tumor stage III/IV samples. |
29754469 |
| cell line |
- |
- |
Cell proliferation assay; Cell colony formation assay;Flow cytometry |
- |
No Reports |
- |
- |
miR-103a-3p increases MKN-45/SGC-7901 cell growth, and miR-103a-3p overexpression promotes the S-G2/M transition in vitro |
miR-103a-3p increases GC cell growth, and miR-103a-3p overexpression promotes the S-G2/M transition in vitro. |
29754469 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
miR-103a-3p directly regulates ATF7 expression in GC cells. |
29754469 |
Function for MIR103A1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR103A1 Gene
| Interaction Gene |
Method |
PMID |
|
ATF7 |
Luciferase reporter assay |
29754469
|
|
