Gastric Cancer Database

Official Symbol	MIR106B	Gene Type	miRNA
Full Name	microRNA 106b	Entrez	406900
Ensembl ID	ENSG00000208036	HGNC	31495
Aliases	MIRN106B, mir-106b	Chromosome Location	Chromosome 7, NC_000007.14 (100093993..100094074, complement)
Expression	-
Summary	microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

PMID	Author	Year	ID in Paper	Conclusion
30907988	Zhenglun Zhu	2019	miR-106b	miR-106b was a potent factor of promoting metastasis of EGC. Moreover, miR-106b inhibitor exhibited anti-cancer characteristics both in vitro and in vivo. The identification of ALEX1 expression correlating to miR-106b highlighted the significance of ALEX1 in miR-106b inhibitor suppressed gastric cancer, suggesting ALEX1 was a direct target of miR-106b. In addition, down-regulation of miR-106b promoted apoptosis of gastric cancer cells through inhibiting JAK/STAT signaling pathway.
29434197	Xingchen Dong	2018	miR-106b	Our results reveal a novel mechanism by which BRD4 regulates cancer cell proliferation by modulating the cellular senescence through E2F/miR-106b-5p/p21 axis and provide new insights into using BET inhibitors as potential anticancer drugs.

Sample Type	Sample Number GC	Sample Number nonGC	Method	Region	Hpylori	Normal vs. GC	Early-stage vs. Advanced stage	Biological Functions in GC Cells	Result	PMID
tissue	10	-	qRT-PCR; FISH	China	No Reports	-	-	-	miR-106b was increased in the metastasis tissues compared with non-metastasis tissues.	30907988
cell line	-	-	Cell invasion and migration assays	-	No Reports	-	-	miR-106b inhibitor could promote the apoptosis of gastric cancer cells	miR-106b inhibitor could promote the apoptosis of gastric cancer cells	30907988
cell line	-	-	Luciferase reporter assay	-	No Reports	-	-	-	miR-106b targeted ALEX1 in gastric cancer cells	30907988
mice	-	-	Xenograft mice models	-	No Reports	-	-	-	Down-regulation of miR-106b inhibited gastric cancer in vivo.	30907988
cell line	-	-	Luciferase reporter assay; Immunoblotting	-	No Reports	-	-	-	miR-106b-5p targets p21 to regulate the cellular senescence in BRD4-inhibited cells. BRD4 regulates miR-106b-5p transcription via E2F for cellular senescence.	29434197

Interaction Gene	Method	PMID
ARMCX1	Luciferase reporter assay	30907988