Search Result
Gene Summary for MIR107 Gene
| Official Symbol |
MIR107 |
Gene Type |
miRNA |
| Full Name |
microRNA 107 |
Entrez |
406901
|
| Ensembl ID |
ENSG00000198997 |
HGNC |
31496
|
| Aliases |
MIRN126, miRNA107, mir-107
|
Chromosome Location |
Chromosome 10, NC_000010.11 (89592747..89592827, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR107 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 26406411 |
Nooshin Ayremlou |
2015 |
miR-107 |
The overexpression of miR-107 in tumors and serum of gastric cancer patients and its correlation with HIF-1α expression in tumor tissues was indicated that miR-107 may have a potential to use as a biomarker for detection of gastric cancer patients and hypoxia in gastric cancer tumor. |
| 26406411 |
Nooshin Ayremlou |
2015 |
miR-107 |
We examined miR-107 expression in GC patient’s serum and age matched healthy controls by quantitative RT-PCR and found significant elevated levels of miR-107 in serum of GC patients compared to controls (P = 0.04). |
Experiment for MIR107 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
36 |
36 |
qRT-PCR |
Iran |
|
Up |
- |
- |
Quantitative RT-PCR analysis on total RNA demonstrated significant overexpression of miR-107 in 36 GC tumor samples, in comparison to the its adjacent normal tissue of the same patients (p = 0.04) |
26406411 |
| serum |
36 |
36 |
qRT-PCR |
Iran |
|
Up |
- |
- |
significant elevated levels of miR-107 in serum of GC patients compared to controls |
26406411 |
Function for MIR107 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| diagnosis |
0.63 |
- |
- |
| target |
- |
- |
- |
Interaction for MIR107 Gene
| Interaction Gene |
Method |
PMID |
|
