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Gene Summary for MIR126 Gene

Official Symbol MIR126 Gene Type miRNA
Full Name microRNA 126 Entrez 406913
Ensembl ID ENSG00000199161 HGNC 31508
Aliases MIRN126, miRNA126, mir-126 Chromosome Location Chromosome 9, NC_000009.12 (136670602..136670686)
Expression -
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIR126 Gene

PMID Author Year ID in Paper
 Conclusion
28260063 Junqing Wang 2017 miR-126 Down-regulated GC cells and directly target ADAM9
25027343 X Li 2014 MiR-126 MiR-126 expression was frequently and markedly downregulated (p < 0.05) in human gastric cancer tissues

Experiment for MIR126 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
cell line - - qRT-PCR - No Reports - - - the expression levels of miR-126 were significantly downregulated in the GC cell lines compared with the GES-1 cells 28260063
cell line - - Luciferase reporter assay - No Reports - - - ADAM9 is a direct target post-transcriptionally regulated by miR-126 in GC cells. 28260063
tissue 15 15 qRT-PCR China No Reports Down - - MiR-126 expression was frequently and markedly downregulated (p < 0.05) in human gastric cancer tissues. Moreover, overexpression of miR-126 significantly decreased (p < 0.05) the protein levels of Crk, which has previously been identified as a direct target of miR-126. Knockdown of Crk also markedly suppressed GC cells invasion. 25027343
tissue 110 - qRT-PCR China No Reports - - - Low expression of miR-126 was significantly associated with lymph-node metastasis and poor histological grade. 25027343
cell line - - Cell proliferation assay; Cell invasion assay - No Reports - - Overexpression of miR-126 inhibited GC cells invasion but did not affect its proliferation in vitro. Overexpression of miR-126 inhibited GC cells invasion but did not affect its proliferation in vitro. 25027343

Function for MIR126 Gene

Functional Type AUC Overall Survival Disease-free Survival
target - - -

Interaction for MIR126 Gene

Interaction Gene Method PMID
ADAM9 Luciferase reporter assay 28260063
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