MKGC: a curated molecular knowledgebase for gastric cancer


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Gene Summary for MIR1275 Gene

Official Symbol MIR1275 Gene Type miRNA
Full Name microRNA 1275 Entrez 100302123
Ensembl ID ENSG00000109320 HGNC 35346
Aliases MIRN1275; mir-1275; hsa-mir-1275 Chromosome Location Chromosome 6, NC_000006.12 (33999972..34000051, complement)
Expression -
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIR1275 Gene

PMID Author Year ID in Paper
 Conclusion
31357957 Jia-Wei Mei 2019 MicroRNA-1275 Increased miR-1275 expression inhibited GC metastasis by regulating vimentin/E-cadherin via direct suppression of JAZF1expression, suggesting that miR-1275 is a tumour-suppressor miRNA with the potential as a prognostic biomarker or therapeutic target in GC.

Experiment for MIR1275 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 120 120 qRT-PCR China Not Related Down - miR-1275 inhibits GC cell invasion and metastasis in vitro and in vivo by targeting JAZF1 The expression of miR-1275 was reduced in GC tissues. We validated in 120 GC patients specimens that low miR-1275 expression levels were closely associated with lymph node metastasis, Borrmann type and poor prognosis. 31357957
cell line - - Cell proliferation assay; Invasion and migration assays - No Reports - - - Ectopic expression of miR-1275 inhibited the metastasis and invasion of GC cells. 31357957
mice - - Xenograft mice models - No Reports - - - Ectopic expression of miR-1275 inhibited the metastasis and invasion in vivo. 31357957
cell line - - Luciferase reporter assay - No Reports - - - JAZF1 is a direct target of miR-1275 in GC cells. 31357957

Function for MIR1275 Gene

Functional Type AUC Overall Survival Disease-free Survival
prognosis - < 0.001 -

Interaction for MIR1275 Gene

Interaction Gene Method PMID
JAZF1 Luciferase reporter assay 31357957
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