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Gene Summary for MIR129-1 Gene
| Official Symbol |
MIR129-1 |
Gene Type |
miRNA |
| Full Name |
microRNA 129-1 |
Entrez |
406917
|
| Ensembl ID |
ENSG00000207705 |
HGNC |
31512
|
| Aliases |
MIR-129b, MIRN129-1, mir-129-1
|
Chromosome Location |
Chromosome 7, NC_000007.14 (128207872..128207943)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR129-1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29879625 |
Qi Liu |
2018 |
miR-129-5p |
miR-129-5p functioned as a tumor suppressor in GC and may be a potential target of GC treatment |
Experiment for MIR129-1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
50 |
50 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
miR-129-5p expression in GC tissues was significantly down regulated than that in adjacent normal tissues; patients with large tumor size and lymph node metastasis significantly associated with lower miR-129-5p expression in GC patients. Patients who had lower miR-129-5p expression predicted poor overall survival time in GC patients. |
29879625 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
miR-129-5p could target the 3′UTR of ADAM9 mRNA and regulated its protein expression |
29879625 |
| cell line |
- |
- |
Cell proliferation assay; Invasion assay |
- |
No Reports |
- |
- |
miR-129-5p overexpression reduced cell proliferation, cell colony formation and cell invasion capacity |
miR-129-5p overexpression reduced cell proliferation, cell colony formation and cell invasion capacity |
29879625 |
Function for MIR129-1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
< 0.05 |
- |
Interaction for MIR129-1 Gene
| Interaction Gene |
Method |
PMID |
|
ADAM9 |
Luciferase reporter assay |
29879625
|
|
