Search Result
Gene Summary for MIR1296 Gene
| Official Symbol |
MIR1296 |
Gene Type |
miRNA |
| Full Name |
microRNA 1296 |
Entrez |
100302150
|
| Ensembl ID |
ENSG00000221063 |
HGNC |
35249
|
| Aliases |
MIRN1296, hsa-mir-1296, mir-1296
|
Chromosome Location |
Chromosome 10, NC_000010.11 (63372957..63373048, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR1296 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30530570 |
Yan Jia |
2019 |
miR-1296 |
Our results indicated a tumor-suppressive role of miR-1296-5p through the translational repression of oncogenic CDK6 and EGFR in gastric cancer. |
Experiment for MIR1296 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
40 |
40 |
qRT-PCR |
China |
No Reports |
- |
- |
- |
miR-1296-5p was down-regulated in gastric cancer tissue and cell lines, and low expression levels of miR-1296-5p were associated with advanced clinical stage. |
30530570 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; |
- |
No Reports |
- |
- |
miR-1296-5p inhibited cell proliferation, migration, and invasion in SGC-7901 and MGC-803 cells. |
miR-1296-5p inhibited cell proliferation, migration, and invasion in SGC-7901 and MGC-803 cells. |
30530570 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
CDK6 and EGFR as novel targets of miR-1296-5p by a luciferase activity assay |
30530570 |
Function for MIR1296 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MIR1296 Gene
| Interaction Gene |
Method |
PMID |
|
CDK6;EGFR |
Luciferase reporter assay |
30530570
|
|
