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Gene Summary for MIR1303 Gene
| Official Symbol |
MIR1303 |
Gene Type |
miRNA |
| Full Name |
microRNA 1303 |
Entrez |
100302284
|
| Ensembl ID |
ENSG00000221552 |
HGNC |
35301
|
| Aliases |
MIRN1303, hsa-mir-1303
|
Chromosome Location |
Chromosome 5, NC_000005.10 (154685776..154685861)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR1303 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 24647998 |
Shi-jie Zhang |
2014 |
miR-1303 |
Downregulation of miR-1303 can inhibit proliferation, migration and invasion of GC cells by targeting CLDN18. |
Experiment for MIR1303 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
45 |
45 |
qRT-PCR |
China |
No Reports |
Up |
Up |
- |
miR-1303 was significantly overexpressed whereas claudin-18 was downregulated in GC tissues and cell lines, which was significantly associated with tumor size, location invasion, histologic type and tumor-node-metastasis stage. |
24647998 |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay |
- |
No Reports |
- |
- |
Cell proliferation rates were reduced, and cell invasion and migratory ability was significantly restricted in miR-1303 inhibitor-transfected groups. |
Cell proliferation rates were reduced, and cell invasion and migratory ability was significantly restricted in miR-1303 inhibitor-transfected groups. |
24647998 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
miR-1303 could bind to the putative binding sites in CLDN18 mRNA 3'-UTR and visibly lower the expression of claudin-18. The introduction of claudin-18 without 3'-UTR restored the miR-1303 promoting migration function. |
24647998 |
Function for MIR1303 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR1303 Gene
| Interaction Gene |
Method |
PMID |
|
CLDN18 |
Luciferase reporter assay |
24647998
|
|
