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Gene Summary for MIR133A1 Gene
| Official Symbol |
MIR133A1 |
Gene Type |
miRNA |
| Full Name |
microRNA 133a-1 |
Entrez |
406922
|
| Ensembl ID |
ENSG00000283927 |
HGNC |
31517
|
| Aliases |
MIRN133A1, mir-133a-1
|
Chromosome Location |
Chromosome 18, NC_000018.10 (21825698..21825785, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR133A1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 25152372 |
Zhenguo Cheng |
2014 |
CDC42 |
Our findings could provide new insights into the molecular mechanisms of gastric carcinogenesis, and may help facilitating development of CDC42/PAK-based therapies for human cancer. |
Experiment for MIR133A1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
180 |
180 |
qRT-PCR |
China |
No Reports |
Down |
Down |
- |
The expression of miR-133 was significantly down-regulated in gastric cancer tissues compared with that in matched normal tissues. Expression of miR-133 is lower in patients above 65 years old than that of below 65 years old. There was a higher level of miR-133 in smaller size tumor. The expression level of miR-133 was lower in T3 and T4 groups than that in T1 and T2 groups. Decreased miR-133 expression was associated with peripheral organ injury and pathologic stages. The survival rate of high-expression group was significantly higher than that the low_x005fexpression group. |
25152372 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
CDC42 is the direct target of miR-133a |
25152372 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays |
- |
No Reports |
- |
- |
miR-133a supresses gastric cancer cell growth, migration and invasion. |
miR-133a supresses gastric cancer cell growth, migration and invasion. |
25152372 |
Function for MIR133A1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
0.003 |
- |
Interaction for MIR133A1 Gene
| Interaction Gene |
Method |
PMID |
|
CDC42 |
Luciferase reporter assay |
25152372
|
|
