Search Result
Gene Summary for MIR135B Gene
| Official Symbol |
MIR135B |
Gene Type |
miRNA |
| Full Name |
microRNA 135b |
Entrez |
442891
|
| Ensembl ID |
ENSG00000199059 |
HGNC |
31760
|
| Aliases |
MIRN135B, mir-135b
|
Chromosome Location |
Chromosome 1, NC_000001.11 (205448302..205448398, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR135B Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 32119960 |
Xiao-Zhan Zhang |
2020 |
miR-135b |
Over-expressed lncRNA PCAT18 inhibits proliferation, migration and invasion of gastric cancer cells through regulation of miR-135b/CLDN11 |
Experiment for MIR135B Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Luciferase reporter assay; RIP |
- |
No Reports |
- |
- |
- |
PCAT18 and CLDN11 are the direct targets of miR-135b |
32119960 |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion and migration assays; Cell colony forming assay; |
- |
No Reports |
- |
- |
Over-expression of miR-135b promotes proliferation, migration and invasion of AGS cells via CLDN11 inhibition. |
Over-expression of miR-135b promotes proliferation, migration and invasion of AGS cells via CLDN11 inhibition. |
32119960 |
Function for MIR135B Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR135B Gene
| Interaction Gene |
Method |
PMID |
|
