Search Result
Gene Summary for MIR136 Gene
| Official Symbol |
MIR136 |
Gene Type |
miRNA |
| Full Name |
microRNA 136 |
Entrez |
406927
|
| Ensembl ID |
ENSG00000207942 |
HGNC |
31522
|
| Aliases |
MIRN136, miRNA136, mir-136
|
Chromosome Location |
Chromosome 14, NC_000014.9 (100884702..100884783)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR136 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30468468 |
L Yu |
2018 |
MiR-136 |
miR-136 promotes apoptosis in gastric cancer cells by targeting AEG-1 and BCL2. Therefore, miR-136 may prove as a potential therapeutic target for the treatment of gastric cancer. |
Experiment for MIR136 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
qRT-PCR |
- |
No Reports |
- |
- |
- |
miR-136 was significantly downregulated in the gastric cancer cell lines as compared to the normal cell line |
30468468 |
| cell line |
- |
- |
Flow cytometry |
- |
No Reports |
- |
- |
- |
transfection of AGS cells with miR-136 promoted apoptosis |
30468468 |
Function for MIR136 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR136 Gene
| Interaction Gene |
Method |
PMID |
|
