MKGC: a curated molecular knowledgebase for gastric cancer


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Gene Summary for MIR137 Gene

Official Symbol MIR137 Gene Type miRNA
Full Name microRNA 137 Entrez 406928
Ensembl ID ENSG00000284202 HGNC 31523
Aliases MIRN137, miR-137 Chromosome Location Chromosome 1, NC_000001.11 (98046070..98046171, complement)
Expression -
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIR137 Gene

PMID Author Year ID in Paper
 Conclusion
26102366 Liping Wu 2015 MicroRNA-137 miR-137 which is frequently down-regulated in gastric cancer is potentially involved in gastric cancer tumorigenesis and metastasis by regulating AKT2 related signal pathways.

Experiment for MIR137 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 100 100 qRT-PCR China No Reports Down Down - Expression of miR-137 in GC tissues was lower than that in adjacent tissues in statistically significant differences. The patients who have the lower levels of miR-137 expression were associated with high-grade and late-stage tumors. 26102366
cell line - - Cell proliferation assay; Invasion and migration assays; Flow cytometry - No Reports - - The re-introduction of miR-137 into gastric cancer cells was able to inhibit cell proliferation, migration and invasion. The re-introduction of miR-137 into gastric cancer cells was able to inhibit cell proliferation, migration and invasion. 26102366
mice - - Xenograft mice models - No Reports - - - The in vivo experiments demonstrated that the miR-137 overexpression can reduce the gastric cancer cell proliferation and metastasis. 26102366
cell line - - Luciferase reporter assay; Western blot - No Reports - - - miR-137 targets AKT2 in GC 26102366

Function for MIR137 Gene

Functional Type AUC Overall Survival Disease-free Survival
mechanism - - -

Interaction for MIR137 Gene

Interaction Gene Method PMID
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