Search Result
Gene Summary for MIR142 Gene
| Official Symbol |
MIR142 |
Gene Type |
miRNA |
| Full Name |
microRNA 142 |
Entrez |
406934
|
| Ensembl ID |
ENSG00000284353 |
HGNC |
31529
|
| Aliases |
MIRN142, mir-142
|
Chromosome Location |
Chromosome 17, NC_000017.11 (58331232..58331318, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR142 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30178386 |
Jing Yan |
2019 |
miR-142 |
miR-142-5p-CYR61-Wnt/β-catenin axis partially illustrates the molecular mechanism of GC recurrence and represents a novel prognosis biomarker for GC. |
Experiment for MIR142 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
101 |
101 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
MiR-142-5p downregulation was significantly associated with the recurrence (P = 0.031) and poor prognosis of GC (P = 0.043). CYR61 was identified as a novel direct target of miR-142-5p by bioinformatics analysis of target prediction and luciferase reporter. The re-expression and knockdown of CYR61 could, respectively, rescue the effects induced by miR-142-5p overexpression and knockdown. MiR-142-5p attenuated GC cell migration and invasion, at least partially, by inactivation of the canonical Wnt/β-catenin signaling pathway through CYR61. |
30178386 |
| cell line |
- |
- |
Cell invasion and migration assays |
- |
No Reports |
- |
- |
MiR-142-5p inhibited cancer cell migration and invasion both in vitro and in vivo. |
MiR-142-5p inhibited cancer cell migration and invasion both in vitro and in vivo. |
30178386 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
MiR-142-5p inhibited cancer cell migration and invasion in vivo. |
30178386 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
CYR61 is a novel target of miR‑142‑5p in GC cells |
30178386 |
Function for MIR142 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target/prognosis |
- |
0.001 |
- |
Interaction for MIR142 Gene
| Interaction Gene |
Method |
PMID |
|
CYR61 |
Luciferase reporter assay |
30178386
|
|
