Search Result
Gene Summary for MIR143 Gene
| Official Symbol |
MIR143 |
Gene Type |
miRNA |
| Full Name |
microRNA 143 |
Entrez |
406935
|
| Ensembl ID |
ENSG00000284182 |
HGNC |
31530
|
| Aliases |
MIRN143, mir-143
|
Chromosome Location |
Chromosome 5, NC_000005.10 (149428918..149429023)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR143 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28404925 |
Fang Wang |
2017 |
MicroRNA-143 |
miR-143-3p acts as a novel tumor suppressive miRNA by regulating tumor growth, migration and invasion through directly targeting AKT2 gene |
Experiment for MIR143 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
42 |
42 |
microarray chip; qRT-PCR |
China |
Related |
Down |
Down |
- |
miR-143-3p was ignificantly increased miRNA in H. pylori-positive gastric cancer tissues and was significantly decreased in gastric cancer tissues and cells, which correlated with late stage and lymph node metastasis. |
28404925 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; Flow cytometry |
- |
No Reports |
- |
- |
Overexpression of miR-143-3p suppressed cell proliferation, induced apoptosis and inhibited cell migration and invasion. |
Overexpression of miR-143-3p suppressed cell proliferation, induced apoptosis and inhibited cell migration and invasion. |
28404925 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
AKT2 is a direct target of miR-143-3p |
28404925 |
Function for MIR143 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR143 Gene
| Interaction Gene |
Method |
PMID |
|
AKT2 |
Luciferase reporter assay |
28404925
|
|
