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Gene Summary for MIR145 Gene
| Official Symbol |
MIR145 |
Gene Type |
miRNA |
| Full Name |
microRNA 145 |
Entrez |
406937
|
| Ensembl ID |
ENSG00000276365 |
HGNC |
31532
|
| Aliases |
MIRN145, miR-145, miRNA145
|
Chromosome Location |
Chromosome 5, NC_000005.10 (149430646..149430733)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR145 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28490034 |
Cheng En Hu |
2017 |
miR-145 |
CRNDE acted as a growth-promoting lncRNA in GC and maybe a potential target of GC treatment. |
Experiment for MIR145 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
20 |
20 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
miR-145 expression was significantly decreased in GC tissues compared with that in adjacent normal tissue samples, and miR-145 level had a significant negative correlation with CRNDE level. |
28490034 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
miR-145 target gene E2F3 was strongly expressed following CRNDE competitive molecular sponging of miR-145. |
28490034 |
Function for MIR145 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MIR145 Gene
| Interaction Gene |
Method |
PMID |
|
E2F3 |
Luciferase reporter assay |
28490034
|
|
