Search Result
Gene Summary for MIR148A Gene
| Official Symbol |
MIR148A |
Gene Type |
miRNA |
| Full Name |
microRNA 148a |
Entrez |
406940
|
| Ensembl ID |
ENSG00000199085 |
HGNC |
31535
|
| Aliases |
MIRN148, MIRN148A, hsa-mir-148, mir-148a
|
Chromosome Location |
Chromosome 7, NC_000007.14 (25949919..25949986, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR148A Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 27518872 |
Beiqin Yu |
2016 |
MiR-148a |
miR-148a-mediated anti-cancer effects are dependent on the inhibition of STAT3 and Akt activation, which subsequently regulates the pathways involved in cell proliferation and migration. |
Experiment for MIR148A Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
41 |
41 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
miR-148a expression was significantly down-regulated in gastric cancer tissues in comparison with the matched normal mucosal tissues, and its expression was statistically associated with lymph node metastasis. |
27518872 |
| cell line |
- |
- |
Cell proliferation assay; Cell migration assays |
- |
No Reports |
- |
- |
Ectopic expression of miR-148a inhibited tumor cell proliferation and migration in vitro. More importantly, siRNA-induced knockdown of CCK-BR elicited similar anti-oncogenic effects (decreased proliferation and migration) as those induced by enforced miR-148a expression. |
Ectopic expression of miR-148a inhibited tumor cell proliferation and migration in vitro. More importantly, siRNA-induced knockdown of CCK-BR elicited similar anti-oncogenic effects (decreased proliferation and migration) as those induced by enforced miR-148a expression. |
27518872 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
Ectopic expression of miR-148a inhibited tumor formation in vivo. |
27518872 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
Cholecystokinin B receptor (CCK-BR) was a direct target of miR-148a |
27518872 |
Function for MIR148A Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR148A Gene
| Interaction Gene |
Method |
PMID |
|
CCKBR |
Luciferase reporter assay |
27518872
|
|
