Search Result
Gene Summary for MIR152 Gene
| Official Symbol |
MIR152 |
Gene Type |
miRNA |
| Full Name |
microRNA 152 |
Entrez |
406943
|
| Ensembl ID |
ENSG00000207947 |
HGNC |
31538
|
| Aliases |
MIRN152, mir-152
|
Chromosome Location |
Chromosome 17, NC_000017.11 (48037161..48037247, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR152 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28427226 |
Yaxin Wang |
2017 |
MicroRNA-152 |
Our work identified a novel mechanism by which immune response is increased by expression of miR-152 via targeting B7-H1. MiR-152 may be a potential therapeutic approach for gastric cancer. |
Experiment for MIR152 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
42 |
42 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
The expression of miR-152 in human gastric cancer tissues were significantly lower than that in matched adjacent normal tissues. Meanwhile, lower miR-152 was also found in gastric cancer cell lines. The stage, tumor size and lymph node metastasis rate were significant higher in low-miR-152 group in clinical patients. |
28427226 |
| cell line |
- |
- |
Cell proliferation assay |
- |
No Reports |
- |
- |
Elevation of miR-152 enhanced T cells proliferation and effector cytokines production via inhibiting B7-H1/PD-1 pathway. |
Elevation of miR-152 enhanced T cells proliferation and effector cytokines production via inhibiting B7-H1/PD-1 pathway. |
28427226 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
miR-152 directly bind to B7-H1 3' untranslated region in gastric cancer cell and inhibited B7-H1 expression. |
28427226 |
Function for MIR152 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR152 Gene
| Interaction Gene |
Method |
PMID |
|
CD274 |
Luciferase reporter assay |
28427226
|
|
