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Gene Summary for MIR155 Gene

Official Symbol MIR155 Gene Type miRNA
Full Name microRNA 155 Entrez 406947
Ensembl ID ENSG00000283904 HGNC 31542
Aliases MIRN155, miRNA155, mir-155 Chromosome Location Chromosome 21, NC_000021.9 (25573980..25574044)
Expression -
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIR155 Gene

PMID Author Year ID in Paper
 Conclusion
26955820 Zhijun Ma 2016 MicroRNA-155 miR-155 may act as a potential diagnostic marker for early-stage GC and may represent a novel therapeutic target for GC treatment.

Experiment for MIR155 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 60 60 qRT-PCR China No Reports Down Down - miR-155 levels were significantly lower in both GC tissues and GC cell lines than in their normal controls, and its expression inversely correlated with tumor size and the pathologic stage. 26955820
cell line - - Cell proliferation assay; Flow cytometry - No Reports - - Enforced expression of miR-155 impaired GC cell proliferation, promoted G1 phase arrest and induced apoptosis in vitro. In addition, we identified cyclin D1 as the direct target of miR-155, and knockdown of cyclin D1 partially phenocopied the role of miR-155 in GC cells. Enforced expression of miR-155 impaired GC cell proliferation, promoted G1 phase arrest and induced apoptosis in vitro. In addition, we identified cyclin D1 as the direct target of miR-155, and knockdown of cyclin D1 partially phenocopied the role of miR-155 in GC cells. 26955820
cell line - - Luciferase reporter assay - No Reports - - - Cyclin D1 is a direct target of miR‐155 in GC cells 26955820

Function for MIR155 Gene

Functional Type AUC Overall Survival Disease-free Survival
target - - -

Interaction for MIR155 Gene

Interaction Gene Method PMID
CCND1 Luciferase reporter assay 26955820
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