Search Result
Gene Summary for MIR15A Gene
| Official Symbol |
MIR15A |
Gene Type |
miRNA |
| Full Name |
microRNA 15a |
Entrez |
406948
|
| Ensembl ID |
ENSG00000283785 |
HGNC |
31543
|
| Aliases |
MIRN15A, hsa-mir-15a, miRNA15A, mir-15a
|
Chromosome Location |
Chromosome 13, NC_000013.11 (50049119..50049201, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR15A Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 26894855 |
Changping Wu |
2016 |
miR-15a |
The expression of Bmi-1 is regulated by miR-15a in gastric cancer. The prognostic significance of Bmi-1 in gastric cancer supports future multi-center large cohort studies. |
Experiment for MIR15A Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
21 |
21 |
qRT-PCR |
China |
No Reports |
- |
- |
- |
The expression of miR-15a is significantly reduced in gastric cancer and the protein expression levels of Bmi-1 are inversely correlated with miR-15a (P = 0.034) in gastric cancer patient samples. |
26894855 |
| cell line |
- |
- |
Cell proliferation assay |
- |
No Reports |
- |
- |
miR-15a suppressed gastric cancer invasion |
miR-15a suppressed gastric cancer invasion; miR-15a suppressed the proliferation of gastric cancer cells via downregulation of Bmi-1. |
26894855 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
Bmi-1 is a direct target of miR-15a in gastric cancer cell lines. |
26894855 |
| tissue |
21 |
- |
qRT-PCR; IHC |
China |
No Reports |
- |
- |
- |
The expression of Bmi-1 is inversely correlated with miR-15a in gastric tumor tissues |
26894855 |
Function for MIR15A Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MIR15A Gene
| Interaction Gene |
Method |
PMID |
|
BMI1 |
Luciferase reporter assay |
26894855
|
|
