Search Result
Gene Summary for MIR181A1 Gene
| Official Symbol |
MIR181A1 |
Gene Type |
miRNA |
| Full Name |
microRNA 181a-1 |
Entrez |
406995
|
| Ensembl ID |
ENSG00000207759 |
HGNC |
31590
|
| Aliases |
MIR213, MIRN181A1, MIRN213, hsa-mir-181a-1, mir-181a-1, mir-213
|
Chromosome Location |
Chromosome 1, NC_000001.11 (198859044..198859153, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR181A1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 24531888 |
Xiangyang Zhang |
2014 |
MicroRNA-181a |
Over-expression of miR-181a might be involved in development of gastric cancer by promoting proliferation and inhibiting apoptosis probably through directly targeting ATM. |
Experiment for MIR181A1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
9 |
9 |
qRT-PCR |
China |
No Reports |
- |
- |
- |
Compared with three non-tumour tissues, the expression of miR-181a in three gastric cancer cells was significantly increased; miR-181a expression was inversely correlated with ATM. |
24531888 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; Cell colony formation assay; Flow cytometry |
- |
No Reports |
- |
- |
- |
miR-181a affects the proliferation and metastatic potential of gastric cancer cells. |
24531888 |
|
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
miR-181a Directly Inhibited the Expression of ATM Through ATM 3'UTR |
24531888 |
Function for MIR181A1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MIR181A1 Gene
| Interaction Gene |
Method |
PMID |
|
ATM |
Luciferase reporter assay |
24531888
|
|
