Search Result
Gene Summary for MIR187 Gene
| Official Symbol |
MIR187 |
Gene Type |
miRNA |
| Full Name |
microRNA 187 |
Entrez |
406963
|
| Ensembl ID |
ENSG00000207797 |
HGNC |
31558
|
| Aliases |
MIRN187, miR-187, miRNA187
|
Chromosome Location |
Chromosome 18, NC_000018.10 (35904818..35904926, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR187 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 27864146 |
Lian Ren |
2017 |
MicroRNA-187 |
miR-187 promotes tumor progression by regulating CRMP1 expression in GC and may thus be a potential prognostic marker and a therapeutic target in GC. |
Experiment for MIR187 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
54 |
54 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
miR-187 was significantly overexpressed in GC tissues compared to that in non-tumor tissues and was associated with malignant clinical factors such as depth of invasion (P = 0.005), tumor size (P = 0.024), lymph node metastasis (P = 0.048), and TNM stage (P = 0.035). |
27864146 |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion and migration assays; |
- |
No Reports |
- |
- |
miR-187 significantly increased migration, invasion, and proliferation, but inhibited apoptosis in GC cells |
miR-187 significantly increased migration, invasion, and proliferation, but inhibited apoptosis in GC cells |
27864146 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
miR-187 promoted tumor growth in vivo |
27864146 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
CRMP1 was a direct downstream target of miR-187 in GC.The effects of miR-187 inhibitor on cell migration and cell apoptosis were reversed by CRMP1 downregulation |
27864146 |
Function for MIR187 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR187 Gene
| Interaction Gene |
Method |
PMID |
|
CRMP1 |
Luciferase reporter assay |
27864146
|
|
