Search Result
Gene Summary for MIR1915 Gene
| Official Symbol |
MIR1915 |
Gene Type |
miRNA |
| Full Name |
microRNA 1915 |
Entrez |
100302129
|
| Ensembl ID |
ENSG00000222071 |
HGNC |
35399
|
| Aliases |
MIRN1915, hsa-mir-1915
|
Chromosome Location |
Chromosome 10, NC_000010.11 (21496562..21496641, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR1915 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 31036603 |
Hong-Wei Cui |
2019 |
miR-1915 |
miR-1915-3p possibly contributes to the development and progression of gastric cancer by inhibiting the anti-apoptotic protein Bcl-2 |
Experiment for MIR1915 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
60 |
60 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
miR-1915-3p exhibited low expression level in differentiated gastric cancer cell lines and gastric cancer tissues. The expressions of miR-1915-3p were significantly correlated to the lymph node metastasis and overall survival of patients with gastric cancer. Further study showed that there was a negative correlation between miR-1915-3p and Bcl-2 (B cell lymphoma/leukemia-2) expression. |
31036603 |
| cell line |
- |
- |
Cell proliferation assay,Cell apoptosis assay |
- |
No Reports |
- |
- |
- |
It was found that the miR-1915-3p inhibited the growth of gastric cancer cells and promoted cell apoptosis. |
31036603 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
miR-1915-3p directly inhibits Bcl-2 expression at post-transcriptional level through its 3'-UTR. |
31036603 |
Function for MIR1915 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
0.01 |
- |
Interaction for MIR1915 Gene
| Interaction Gene |
Method |
PMID |
|
BCL2 |
Luciferase reporter assay |
31036603
|
|
