Search Result
Gene Summary for MIR193A Gene
| Official Symbol |
MIR193A |
Gene Type |
miRNA |
| Full Name |
microRNA 193a |
Entrez |
406968
|
| Ensembl ID |
ENSG00000207614 |
HGNC |
31563
|
| Aliases |
MIRN193, MIRN193A, mir-193a
|
Chromosome Location |
Chromosome 17, NC_000017.11 (31559996..31560083)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR193A Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29848678 |
Nan-Hua Chou |
2018 |
miR-193a-3p |
miR-193a-3p suppressed gastric growth and motility, at least partly, by directly targeting CCND1 and ETS1 expression. |
Experiment for MIR193A Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Cell proliferation assay; Cell colony formation assay; |
- |
No Reports |
- |
- |
Ectopic expressions of miR-193a-5p and miR-193a-3p revealed that they both inhibited gastric cancer cell growth, but only miR-193a-3p significantly suppressed cell invasion ability. |
Ectopic expressions of miR-193a-5p and miR-193a-3p revealed that they both inhibited gastric cancer cell growth, but only miR-193a-3p significantly suppressed cell invasion ability. |
29848678 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
ETS1 and CCND1 are direct target of miR-193a-3p |
29848678 |
Function for MIR193A Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MIR193A Gene
| Interaction Gene |
Method |
PMID |
|
ETS1;CCND1 |
Luciferase reporter assay |
29848678
|
|
