Search Result
Gene Summary for MIR193B Gene
| Official Symbol |
MIR193B |
Gene Type |
miRNA |
| Full Name |
microRNA 193b |
Entrez |
574455
|
| Ensembl ID |
ENSG00000207639 |
HGNC |
32087
|
| Aliases |
MIRN193B, mir-193b
|
Chromosome Location |
Chromosome 16, NC_000016.10 (14303967..14304049)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR193B Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 27071318 |
Lanlan Wang |
2016 |
miR-193b |
Overexpression of miR-193b inhibited the expression of CCND1, and knock-down of CCND1 inhibited the proliferation of GC cells, suggesting that miR-193b exerted its anti-tumorigenic role in GC cells through targeting CCND1 gene. |
Experiment for MIR193B Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
50 |
50 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
miR-193b was significantly reduced in GC tissues compared with the adjacent normal gastric tissues. Moreover, lower-level of miR-193b was also associated with a more aggressive GC phenotype. |
27071318 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays |
- |
No Reports |
- |
- |
- |
miR-193b can inhibit the proliferation, migration and invasion of HGC-27 and MGC-803 GC cells. |
27071318 |
Function for MIR193B Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MIR193B Gene
| Interaction Gene |
Method |
PMID |
|
