Search Result
Gene Summary for MIR194-1 Gene
| Official Symbol |
MIR194-1 |
Gene Type |
miRNA |
| Full Name |
microRNA 203a |
Entrez |
406986
|
| Ensembl ID |
ENSG00000207568 |
HGNC |
31581
|
| Aliases |
MIR203, MIRN203, hsa-mir-203a, miR-203, miRNA203, mir-203a
|
Chromosome Location |
Chromosome 14, NC_000014.9 (104117405..104117514)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR194-1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 27810403 |
Yin Peng |
2017 |
MiRNA-194 |
miRNA-194 is oncogenic and promotes GC cell proliferation and migration by activating Wnt signaling, at least in part, via suppression of SUFU. |
Experiment for MIR194-1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
43 |
43 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
MiRNA-194 was found to be overexpressed in GC cell lines and 43 paired GC tissues. |
27810403 |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion and migration assays |
- |
No Reports |
- |
- |
Overexpression of miRNA-194 promoted cell proliferation and migration, while inhibition of miRNA-194 blocked these processes. |
Overexpression of miRNA-194 promoted cell proliferation and migration, while inhibition of miRNA-194 blocked these processes. |
27810403 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
Inhibition of miRNA-194 decreased tumor volumes in nude mice. |
27810403 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
SUFU is the functional target of miRNA-194 |
27810403 |
Function for MIR194-1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR194-1 Gene
| Interaction Gene |
Method |
PMID |
|
SUFU |
Luciferase reporter assay |
27810403
|
|
