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Gene Summary for MIR198 Gene
| Official Symbol |
MIR198 |
Gene Type |
miRNA |
| Full Name |
microRNA 198 |
Entrez |
406975
|
| Ensembl ID |
ENSG00000284121 |
HGNC |
31570
|
| Aliases |
MIRN198, miR-198
|
Chromosome Location |
Chromosome 3, NC_000003.12 (120395668..120395729, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR198 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30927924 |
Xiaoxu Huang |
2019 |
miR-198 |
circAKT3 plays an important role in the resistance of GC to CDDP. Thus, our results highlight the potential of circAKT3 as a therapeutic target for GC patients receiving CDDP therapy. |
Experiment for MIR198 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Cell cytotoxicity assay; Clonogenic assay; Flow ytometry |
- |
No Reports |
- |
- |
Overexpression of miR-198 inhibited cell viability and induced apoptosis in SGC7901CDDP and BGC823CDDP cells. |
Overexpression of miR-198 inhibited cell viability and induced apoptosis in SGC7901CDDP and BGC823CDDP cells. |
30927924 |
| cell line |
- |
- |
Luciferase reporter assay: RNA pull-down; FISH |
- |
No Reports |
- |
- |
- |
circAKT3 and miR-198 were colocalized in the cytoplasm; circAKT3 exerts its function by sponging miR-198. |
30927924 |
Function for MIR198 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MIR198 Gene
| Interaction Gene |
Method |
PMID |
|
