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Gene Summary for MIR199A1 Gene

Official Symbol MIR199A1 Gene Type miRNA
Full Name microRNA 199a-1 Entrez 406976
Ensembl ID ENSG00000207752 HGNC 31571
Aliases MIR-199-s; MIRN199A1; mir-199a-1 Chromosome Location Chromosome 19, NC_000019.10 (10817426..10817496, complement)
Expression -
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIR199A1 Gene

PMID Author Year ID in Paper
 Conclusion
30193607 Chao Yan 2018 MicroRNA-199 The over-expression of miR-199 in gastric carcinoma is associated with the decreased ability of proliferation and migration of gastric carcinoma cells by targeting TBL1XR1.

Experiment for MIR199A1 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 51 51 qRT-PCR China No Reports Down - - The relative expression of miR-199 in gastric carcinoma tissues was significantly lower than that in the adjacent normal tissue . 30193607
cell line - - Cell proliferation assay; Cell migration assay - No Reports - - Over-expression of miR-199 inhibited the proliferation and migration of GC cells. Over-expression of miR-199 inhibited the proliferation and migration of GC cells. 30193607
cell line - - Luciferase reporter assay - No Reports - - - miR-199 directly targeted on the 3' untranslated region of TBL1XR1. 30193607

Function for MIR199A1 Gene

Functional Type AUC Overall Survival Disease-free Survival
target - - -

Interaction for MIR199A1 Gene

Interaction Gene Method PMID
TBL1XR1 Luciferase reporter assay 30193607
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