Search Result
Gene Summary for MIR19A Gene
| Official Symbol |
MIR19A |
Gene Type |
miRNA |
| Full Name |
microRNA 19a |
Entrez |
406979
|
| Ensembl ID |
ENSG00000284204 |
HGNC |
31574
|
| Aliases |
C13orf25, MIR17HG, MIRH1, MIRHG1, MIRN19A, hsa-mir-19a, miR-19a, miRNA19A
|
Chromosome Location |
Chromosome 13, NC_000013.11 (91350891..91350972)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR19A Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 25914465 |
Wei-Dong Lu |
2015 |
MiR-19a |
miR-19a could be used as a promising therapeutic target in the treatment of GC. |
Experiment for MIR19A Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
50 |
50 |
qRT-PCR |
China |
No Reports |
Up |
Up |
- |
miR19a is increased in GC tissue samples and cell lines. Overexpression of miR-19a was significantly associated with metastasis of GC. |
25914465 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays |
- |
No Reports |
- |
- |
Overexpression of miR-19a promoted the proliferation, migration and invasion. |
Overexpression of miR-19a promoted the proliferation, migration and invasion. |
25914465 |
| cell line |
- |
- |
Western blot |
- |
No Reports |
- |
- |
- |
Overexpressing miR19a GC cells promoted phosphorylation of PI3KAKT, and the phosphorylation of PI3KAKT was blocked in the cells transfected with miR-19a mimic. |
25914465 |
Function for MIR19A Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR19A Gene
| Interaction Gene |
Method |
PMID |
|
