Gastric Cancer Database

Official Symbol	MIR204	Gene Type	miRNA
Full Name	microRNA 204	Entrez	406987
Ensembl ID	ENSG00000207935	HGNC	31582
Aliases	MIRN204, RDICC, miRNA204, mir-204	Chromosome Location	Chromosome 9, NC_000009.12 (70809975..70810084, complement)
Expression	-
Summary	microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

PMID	Author	Year	ID in Paper	Conclusion
29386218	Xin Chen	2018	miR-204-5p	LINC01234 is significantly overexpressed in gastric cancer, and LINC01234-miR-204-5p-CBFB axis plays a critical role in gastric cancer tumorigenesis.
23152059	A Sacconi	2012	miR-204	Modulation of aberrant expression of miR-204, which in turn releases oncogenic Bcl-2 protein activity might hold promise for preventive and therapeutic strategies of GC.

Sample Type	Sample Number GC	Sample Number nonGC	Method	Region	Hpylori	Normal vs. GC	Early-stage vs. Advanced stage	Biological Functions in GC Cells	Result	PMID
tissue	50gc, 50 non-gc		CDX		Not Related	-	-	suppress LINC01234	LINC01234 expression was significantly upregulated in gastric cancer tissues and was associated with larger tumor size, advanced TNM stage, lymph node metastasis, and shorter survival time. Furthermore, knockdown of LINC01234-induced apoptosis and growth arrest in vitro and inhibited tumorigenesis in mouse xenografts.	29386218
tissue	84	84	qRT-PCR	Italy	No Reports	Down	Down	-	miR-204 is downregulated in gastric tumor samples and advanced stages of GC; miR-204 is a prognostic factor for GCs.	23152059
cell line	-	-	Luciferase reporter assay	-	No Reports	-	-	-	miR-204-mediated targeting of Bcl-2 expression pro_x005fmotes apoptosis of GC cells.	23152059
cell line	-	-	Cell migration assay; Cell colony formation assay; Cell apoptosis assay	-	No Reports	-	-	miR-204 overexpression affects cell migration, colony forming ability and chemoresistance.	miR-204 overexpression affects cell migration, colony forming ability and chemoresistance.	23152059

Interaction Gene	Method	PMID
BCL2	Luciferase reporter assay	23152059