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Gene Summary for MIR208A Gene

Official Symbol MIR208A Gene Type miRNA
Full Name microRNA 208a Entrez 406990
Ensembl ID ENSG00000199157 HGNC 31585
Aliases MIR208; MIRN208; MIRN208A; miRNA208; hsa-mir-208a Chromosome Location Chromosome 14, NC_000014.9 (23388596..23388666, complement)
Expression -
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIR208A Gene

PMID Author Year ID in Paper
 Conclusion
29886152 Hai-Bin Cui 2018 MiR-208a miR-208a promoted GC progression by targeting SFRP1 and negatively regulating MEG3, which may be a potential therapeutic target of GC.
27634902 Kai Yin 2016 miR-208a this study revealed a critical role for miR-208a-3p as an oncogenic miRNA in gastric carcinogenesis and it may provide a potential novel target for gastric cancer diagnosis and therapy

Experiment for MIR208A Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 62 62 qRT-PCR China No Reports Up Up - miR-208a expression was significantly increased in GC tissues compared with adjacent normal tissues. Higher miR-208a expression was association with lymph node metastasis and TNM stage in GC patients. Kaplan-Meier analysis verified that patients with higher miR-208a expression were significantly associated with shorter overall survival (OS) time. miR-208a expression negatively associated with MEG3. 29886152
cell line - - Cell proliferation assay; Cell invasion assay; - No Reports - - Ectopic expression of miR-208a by treatment with miR-208a mimic promoted cell proliferation and invasion abilities, but downregulation of miR-208a by treatment with miR-208a inhibitor had an opposite effects. Ectopic expression of miR-208a by treatment with miR-208a mimic promoted cell proliferation and invasion abilities, but downregulation of miR-208a by treatment with miR-208a inhibitor had an opposite effects. 29886152
cell line - - Luciferase reporter assay - No Reports - - - SFRP1 is a direct target of MiR-208a in GC cells 29886152
cell line - - Luciferase reporter assay; RIP - No Reports - - - MEG3 is a bona fide target for miR-208a in GC cells 29886152
tissue 16 16 qRT-PCR China No Reports Up - - miR-208a-3p was up-regulated in GC tissues 27634902
cell line - - Flow cytometry - No Reports - - miR-208a-3p suppresses apoptosis of gastric cancer cells by targeting PDCD4 miR-208a-3p suppresses apoptosis of gastric cancer cells by targeting PDCD4 27634902
cell line - - Luciferase reporter assay - No Reports - - - PDCD4 is a direct target of miR-208a-3p 27634902
mice - - Xenograft mice models - No Reports - - - miR-208a-3p promoted the development of tumor growth 27634902

Function for MIR208A Gene

Functional Type AUC Overall Survival Disease-free Survival
target/prognosis - < 0.05 -
target - - -

Interaction for MIR208A Gene

Interaction Gene Method PMID
SFRP1; MEG3 Luciferase reporter assay 29886152
PDCD4 Luciferase reporter assay 27634902
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