Search Result
Gene Summary for MIR21 Gene
| Official Symbol |
MIR21 |
Gene Type |
miRNA |
| Full Name |
microRNA 21 |
Entrez |
406991
|
| Ensembl ID |
ENSG00000284190 |
HGNC |
31586
|
| Aliases |
MIRN21, hsa-mir-21, miR-21, miRNA21
|
Chromosome Location |
Chromosome 17, NC_000017.11 (59841266..59841337)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR21 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30700111 |
Hao Zhou |
2019 |
miRNA-21 |
miR-21 targets PTEN/Akt signaling pathway and regulates cell proliferation, migration and apoptosis in human gastric cancer cells. Our findings may provide a therapeutic target for treatment of human gastric cancer. |
Experiment for MIR21 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Cell proliferation assay; Migration assay; Flow cytometer; Cell cycle assay |
- |
No Reports |
- |
- |
Down-regulation of miR-21 markedly reduced gastric cancer cell proliferation and promoted cell apoptosis and repressed cell cycle progression; Silencing miR-21 dramatically blocked gastric cancer cell migration and movement. |
Down-regulation of miR-21 markedly reduced gastric cancer cell proliferation and promoted cell apoptosis and repressed cell cycle progression; Silencing miR-21 dramatically blocked gastric cancer cell migration and movement. |
30700111 |
Function for MIR21 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR21 Gene
| Interaction Gene |
Method |
PMID |
Gene Summary for MIR217 Gene
| Official Symbol |
MIR217 |
Gene Type |
miRNA |
| Full Name |
microRNA 217 |
Entrez |
406999
|
| Ensembl ID |
ENSG00000207548 |
HGNC |
31594
|
| Aliases |
MIRN217, mir-217
|
Chromosome Location |
Chromosome 2, NC_000002.12 (55982967..55983076, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR217 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30063010 |
Wei Li |
2018 |
MiR-217 |
we constructed the negative correlation between miR-217 and CDH1 level in GC patients and cells |
Experiment for MIR217 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| exosomes in plasma |
67 |
67 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
Exosomal miR-217 was increased in the GC patients. |
30063010 |
| tissue |
67 |
67 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
The expression of miR-217 was significantly up-regulated in GC tissues. |
30063010 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
CDH1 is a direct target of miR-217 |
30063010 |
| cell line |
- |
- |
Cell proliferation assay; Flow cytometry |
- |
No Reports |
- |
- |
miR-217 overexpression contributes to increased GC cells proliferation。 |
miR-217 overexpression contributes to increased GC cells proliferation |
30063010 |
Function for MIR217 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MIR217 Gene
| Interaction Gene |
Method |
PMID |
|
CDH1 |
Luciferase reporter assay |
30063010
|
|
