Search Result
Gene Summary for MIR222 Gene
| Official Symbol |
MIR222 |
Gene Type |
miRNA |
| Full Name |
microRNA 222 |
Entrez |
407007
|
| Ensembl ID |
ENSG00000207725 |
HGNC |
31602
|
| Aliases |
MIRN222, miRNA222, mir-222
|
Chromosome Location |
Chromosome X, NC_000023.11 (45747015..45747124, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR222 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 25129310 |
Zhengchuan Fu |
2014 |
miRNA-222 |
In conclusion, our findings suggested that circulating miR-222 in plasma might be a potential and useful noninvasive biomarker for the early detection and prognosis of GC |
| 22432036 |
Ming-yang Song |
2012 |
miR-222 |
miR-222 demonstrated significantly elevated levels in GC group with more than 2-fold change(P<0.05) |
Experiment for MIR222 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| plasma |
114 |
56 |
qRT-PCR |
China |
|
UP |
- |
- |
In this study, our results demonstrated that the levels of circulating miR-222 in patients with GC were significantly increased, compared with CAG and healthy controls. In addition, higher level of circulating miR-222 had also been found in the plasma of CAG patients compared with healthy controls, indicating the dysregulated expression of miR-222 might be involved in the early events of GC malignancy. |
25129310 |
| serum |
82 |
82 |
qRT-PCR |
- |
|
UP |
- |
- |
miR-222 demonstrated significantly elevated levels in GC group with more than 2-fold change(P<0.05) |
22432036 |
Function for MIR222 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target;prognosis |
0.85 |
22.428 % |
25.267% |
| target |
0.65 |
- |
- |
Interaction for MIR222 Gene
| Interaction Gene |
Method |
PMID |
|
