Search Result
Gene Summary for MIR27A Gene
| Official Symbol |
MIR27A |
Gene Type |
miRNA |
| Full Name |
microRNA 27a |
Entrez |
407018
|
| Ensembl ID |
ENSG00000207808 |
HGNC |
31613
|
| Aliases |
MIR27, MIRN27A, mir-27a
|
Chromosome Location |
Chromosome 19, NC_000019.10 (13836440..13836517, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR27A Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 27409164 |
Lin Zhou |
2016 |
MiR-27a-3p |
miR-27a-3p/BTG2 axis might represent a promising diagnostic biomarker for gastric cancer patients and could be a potential therapeutic target in the management of gastric cancer. |
Experiment for MIR27A Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
20 |
20 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
Two isoforms of mature miR-27a, miR-27a-5p and miR-27-3p, were both frequently overexpressed in gastric cancer tissues and cell lines, whereas the expression level of miR-27-3p in gastric cancer was significantly higher than that of miR-27a-5p. |
27409164 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; Flow cytometry; Apotosis assay |
- |
No Reports |
- |
- |
Overexpression of miR-27a-3p markedly promoted gastric cancer cell proliferation in vitro. |
Overexpression of miR-27a-3p, but not miR-27a-5p, markedly promoted gastric cancer cell proliferation in vitro. miR-27a-3p/BTG2 axis regulates cell cycle progression and apoptosis in gastric cancer cells |
27409164 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
miR-27a-3p promotes GC cell growth in vivo. |
27409164 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
BTG2 was a direct and functional target of miR-27a-3p in gastric cancer and miR-27a-3p inhibition obviously up-regulated the expression of BTG2. |
27409164 |
Function for MIR27A Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR27A Gene
| Interaction Gene |
Method |
PMID |
|
BTG2 |
Luciferase reporter assay |
27409164
|
|
