Search Result
Gene Summary for MIR29A Gene
| Official Symbol |
MIR29A |
Gene Type |
miRNA |
| Full Name |
microRNA 29a |
Entrez |
407021
|
| Ensembl ID |
ENSG00000284032 |
HGNC |
31616
|
| Aliases |
MIRN29; MIRN29A; mir-29a; miRNA29A; hsa-mir-29; hsa-mir-29a
|
Chromosome Location |
Chromosome 7,NC_000007.14 (130876747..130876810, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR29A Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 25428377 |
Hongkai Zhang |
2015 |
MicroRNA-29s |
AKT2 may be one of the targets of miR29s in gastric cancer |
Experiment for MIR29A Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
20 |
20 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
Down-regulated in GC tissues compared with non-tumor tissues and had the tendency of inversely relationship with the expression of AKT2. |
25428377 |
| cell line |
- |
- |
Cell invasion assay |
- |
No Reports |
- |
- |
Introduction of miR-29a into GC cells resulted in decreased AKT2 expression and decreased the ability of cancer cells invasion, so did the siRNA-AKT2. |
Introduction of miR-29a into GC cells resulted in decreased AKT2 expression and decreased the ability of cancer cells invasion, so did the siRNA-AKT2. |
25428377 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
AKT2 was the direct target of the miR-29a in GC cells. |
25428377 |
Function for MIR29A Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR29A Gene
| Interaction Gene |
Method |
PMID |
|
AKT2 |
Luciferase reporter assay |
25428377
|
|
