Search Result
Gene Summary for MIR331 Gene
| Official Symbol |
MIR331 |
Gene Type |
miRNA |
| Full Name |
microRNA 331 |
Entrez |
442903
|
| Ensembl ID |
ENSG00000199172 |
HGNC |
31772
|
| Aliases |
MIRN331, hsa-mir-331, mir-331
|
Chromosome Location |
Chromosome 12, NC_000012.12 (95308420..95308513)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR331 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 31182928 |
Luo Zhang |
2019 |
MiR-331-3p |
The circCACTIN/miR-331-3p/TGFBR1 axis affected the proliferation, migration, invasion and EMT of GC through the mechanism of competing endogenous RNAs (ceRNA). Furthermore, our results identified circCACTIN as a novel oncogenic circRNA in GC. |
Experiment for MIR331 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays |
- |
No Reports |
- |
- |
Transfection of miR-331-3p inhi- bitor promoted BGC-823 cells proliferation, invasion and migration; transfection of miR-331-3p mimic suppressed MGC-803 cells proliferation, invasion and migration. |
Transfection of miR-331-3p inhi- bitor promoted BGC-823 cells proliferation, invasion and migration; transfection of miR-331-3p mimic suppressed MGC-803 cells proliferation, invasion and migration. |
31182928 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
Binding interaction exists between miR-331-3p and TGFBR1, circCACTIN and miR-331-3p |
31182928 |
| cell line |
- |
- |
qRT-PCR; Western blot |
- |
No Reports |
- |
- |
- |
Both TGFBR1 mRNA and protein expression were regulated by circCACTIN through miR-331-3p |
31182928 |
Function for MIR331 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR331 Gene
| Interaction Gene |
Method |
PMID |
|
circCACTIN; TGFBR1 |
Luciferase reporter assay |
31182928
|
|
