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Gene Summary for MIR338 Gene

Official Symbol MIR338 Gene Type miRNA
Full Name microRNA 338 Entrez 442906
Ensembl ID ENSG00000283604 HGNC 31775
Aliases MIRN338, hsa-mir-338, mir-338 Chromosome Location Chromosome 17, NC_000017.11 (81125883..81125949, complement)
Expression -
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIR338 Gene

PMID Author Year ID in Paper
 Conclusion
30308487 Bo Guo 2018 miR-338-3p miR-338-3p functions as a tumor suppressor in GC, and that the hypermethylation status of its CpG island might be a novel potential strategy for treating GC.
26617808 Jiang-Tao Chen 2015 MiR-338-3p miR-338-3p is significantly decreased in gastric cancer, and inhibits cell proliferation, migration and invasion partially via the downregulation of ADAM17.
25945841 Na Huang 2015 MiR-338-3p miR-338-3p inhibited the EMT progression in GC cells by targeting ZEB2 and MACC1/Met/Akt signaling

Experiment for MIR338 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 53 53 qRT-PCR China No Reports Down - - miR-338-3p was down-regulated in both GC tissues (53 paired samples) and cell lines (4 cancer cell lines). The decreased expression of miR-338-3p was found to be significantly associated with the Borrmann stage. 30308487
cell line - - Cell proliferation assay; Invasion and migration assays - No Reports - - miR-338-3p could suppress cell proliferation and induce cell apoptosis. miR-338-3p could suppress cell proliferation and induce cell apoptosis, suppresses metastasis 30308487
cell line - - Bisulfite sequence - No Reports - - - hyper-methylation is the main cause of miR-338-3p depression 30308487
cell line - - Luciferase reporter assay - No Reports - - - Rab14 is a direct target of miR-338-3p; miR-338-3p suppresses metastasis by targeting the Hhat-MMP signaling pathway 30308487
tissue 36 36 qRT-PCR China No Reports Down - - Down-regulated in both gastric cancer cell lines and tissues. 26617808
cell line - - Cell proliferation assay; Invasion and migration assays; - No Reports - - Enforced expression of miR-338-3p inhibited proliferation, migration and invasion of gastric cancer cells in vitro Enforced expression of miR-338-3p inhibited proliferation, migration and invasion of gastric cancer cells in vitro 26617808
cell line - - Luciferase reporter assay - No Reports - - - ADAM17 is a direct target of miR-338-3 and prescued the miR-338-3p mediated inhibition of cell proliferation, migration and invasion 26617808
tissue 20 20 qRT-PCR China No Reports Down Down - miR-338-3p was significantly lower in GC tissues than in the corresponding adjacent noncancerous tissues; mRNA expression of miR-338-3p was even lower in advanced stages of GC compared to that observed in the early stages. 25945841
cell line - - Cell invasion and migration assays - No Reports - - miR-338-3p inhibited the migration and invasion of GC cells in vitro and inhibits the EMT process in GC cells. miR-338-3p inhibited the migration and invasion of GC cells in vitro and inhibits the EMT process in GC cells. 25945841
cell line - - Luciferase reporter assay - No Reports - - - miR-338-3p directly targeted zinc finger E-box-binding protein 2 (ZEB2) and metastasis-associated in colon cancer-1 (MACC1). 25945841

Function for MIR338 Gene

Functional Type AUC Overall Survival Disease-free Survival
target - - -

Interaction for MIR338 Gene

Interaction Gene Method PMID
Rab14; Hhat Luciferase reporter assay 30308487
ADAM17 Luciferase reporter assay 26617808
ZEB2 Luciferase reporter assay 25945841
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