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Gene Summary for MIR340 Gene
| Official Symbol |
MIR340 |
Gene Type |
miRNA |
| Full Name |
microRNA 340 |
Entrez |
442908
|
| Ensembl ID |
ENSG00000198995 |
HGNC |
31777
|
| Aliases |
MIRN340, hsa-mir-340, mir-340
|
Chromosome Location |
Chromosome 5, NC_000005.10 (180015303..180015397, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR340 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28057912 |
Jinzhong Yu |
2017 |
miR-340 |
miR-340 can inhibit proliferation and induce apoptosis of SGC-7901 cells, |
Experiment for MIR340 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; Flow cytometry |
- |
No Reports |
- |
- |
Overexpression of miR-340 significantly reduced cell viability and proliferation, and induced cell apoptosis of GC cells |
Overexpression of miR-340 significantly reduced cell viability and proliferation, and induced cell apoptosis of GC cells |
28057912 |
Function for MIR340 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for MIR340 Gene
| Interaction Gene |
Method |
PMID |
|
