Search Result
Gene Summary for MIR34A Gene
| Official Symbol |
MIR34A |
Gene Type |
miRNA |
| Full Name |
microRNA 34a |
Entrez |
407040
|
| Ensembl ID |
ENSG00000284357 |
HGNC |
31635
|
| Aliases |
MIRN34A, miRNA34A, mir-34, mir-34a
|
Chromosome Location |
Chromosome 1, NC_000001.11 (9151668..9151777, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. [provided by RefSeq, Sep 2015]
|
Paper for MIR34A Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 24068565 |
Weiguo Cao |
2014 |
miR-34a |
miR-34a over-expression could improve the sensitivity of gastric cancer cells against cisplatin-based chemotherapies, with PI3K/AKT/survivin signaling pathway possibly involved in the mechanism. |
| 23264087 |
Weiguo Cao |
2013 |
miRNA-34a |
The expression level of miR-34a was downregulated in human gastric cancer cell lines. miR-34a can negatively regulate survivin protein expression and inhibit gastric cancer cell proliferation and invasion. Therapeutically enhancing miR-34a expression or silencing the survivin gene may benefit patients with gastric cancer. |
Experiment for MIR34A Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
qRT-PCR |
- |
No Reports |
- |
- |
- |
miR-34a expression was down-regulated in cisplatin-resistant cell lines |
24068565 |
| cell line |
- |
- |
Cell viability assay; Flow cytometry |
- |
No Reports |
- |
- |
The over-expression of miR- 34a could improve the sensitivity of gastric cancer cells to cisplatin-based chemotherapies |
The over-expression of miR- 34a could improve the sensitivity of gastric cancer cells to cisplatin-based chemotherapies |
24068565 |
| cell line |
- |
- |
qRT-PCR |
- |
No Reports |
- |
- |
- |
miR-34a expression in gastric cancer cells was significantly reduced compared to the normal gastric epithelial cell line. |
23264087 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; Flow cytometry |
- |
No Reports |
- |
- |
In the overexpressing miR-34a in HGC-27 cells, cellular viability was significantly reduced, the proliferation index decreased significantly and cellular apoptosis was significantly increased, the number of cells passing through the transwell chamber was significantly reduced. |
In the overexpressing miR-34a in HGC-27 cells, cellular viability was significantly reduced, the proliferation index decreased significantly and cellular apoptosis was significantly increased, the number of cells passing through the transwell chamber was significantly reduced. |
23264087 |
Function for MIR34A Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MIR34A Gene
| Interaction Gene |
Method |
PMID |
|
