MKGC: a curated molecular knowledgebase for gastric cancer


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Gene Summary for MIR381 Gene

Official Symbol MIR381 Gene Type miRNA
Full Name microRNA 381 Entrez 494330
Ensembl ID ENSG00000199020 HGNC 31874
Aliases MIRN381, hsa-mir-381, mir-381 Chromosome Location Chromosome 14, NC_000014.9 (101045920..101045994)
Expression -
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Paper for MIR381 Gene

PMID Author Year ID in Paper
 Conclusion
28193228 Qinghua Cao 2017 MicroRNA-381 MiR-381 may function as a tumor suppressor by directly targeting TMEM16A and regulating TGF-?pathway and EMT process in the development of progression of gastric cancer

Experiment for MIR381 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 103 103 qRT-PCR China No Reports Down - - MiR-381 was significantly down-regulated in gastric cancer tissues and cell lines. Low expression of miR-381 was negatively related to lymph node metastasis, advanced tumor stage and poor prognosis.miR-381 and TMEM16A revealed the improved prognostic accuracy for gastric cancer patients. 28193228
cell line - - Cell proliferation assay; Invasion and migration assays - No Reports - - MiR-381 decreased gastric cancer cell proliferation, migration and invasion in vitro. MiR-381 decreased gastric cancer cell proliferation, migration and invasion in vitro. 28193228
mice - - Xenograft mice models - No Reports - - - MiR-381 decreased gastric cancer cell proliferation, migration and invasion in vivo. 28193228
cell line - - Luciferase reporter assay; Western blot; IHC - No Reports - - - TMEM16A was identified as a direct target of miR-381 and the expression of miR-381 was inversely correlated with TMEM16A expression in gastric cancer tissues 28193228

Function for MIR381 Gene

Functional Type AUC Overall Survival Disease-free Survival
target/prognosis - 0.024 0.037

Interaction for MIR381 Gene

Interaction Gene Method PMID
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