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Gene Summary for MIR421 Gene
| Official Symbol |
MIR421 |
Gene Type |
miRNA |
| Full Name |
microRNA 421 |
Entrez |
693122
|
| Ensembl ID |
ENSG00000202566 |
HGNC |
32793
|
| Aliases |
MIRN421, hsa-mir-421
|
Chromosome Location |
Chromosome X, NC_000023.11 (74218377..74218461, complement)
|
| Expression |
-
|
| Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
|
Paper for MIR421 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 25041019 |
Jian-Hong Wu |
2014 |
MiR-421 |
miR-421 acts as a tumor promoter by targeting the caspase-3 gene and preventing apoptosis of gastric cancer cells through inhibition of caspase-3 expression |
Experiment for MIR421 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
50 |
50 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
miR-421 was over-expressed in gastric cancer tissues and cell lines. Caspase-3 was negatively regulated by miR-421 at the post-transcriptional level. |
25041019 |
| cell line |
- |
- |
Cell proliferation assay |
- |
No Reports |
- |
- |
The over-expression of miR-421 promoted gastric cancer cell growth and inhibited apoptosis of the BGC-823 gastric cancer cell line. |
The over-expression of miR-421 promoted gastric cancer cell growth and inhibited apoptosis of the BGC-823 gastric cancer cell line. |
25041019 |
Function for MIR421 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for MIR421 Gene
| Interaction Gene |
Method |
PMID |
|
